Active Solvent Modulation (ASM) is a solution for improving solvent compatibility between the first and the second dimension.
The ¹D solvent in the sample loop may impair separation if it has a high elution strength with respect to the second dimension column. This may result in unretained elution, broad and distorted peaks, often with a loss of separation. ASM modulates the content of the sampling loop by temporary dilution with weak solvent before it reaches the ²D column. In this way, the analytes in the sample are focused on the column head. After the enrichment of the analytes, the valve switches to its final through-loop position. This workflow is enabled by the 2D-LC Valve ASM G4243A.
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id: 3443937547